Since 1967, Museum Vleeshuis has kept the magisterial Dulcken harpsichord on permanent loan from the Royal Conservatory of Antwerp. Historic keyboard player Korneel Bernolet is an ambassador for the instrument.
Two dance organs and a fairground organ from the Ghysels collection have received "Masterpiece" status. As such, they are recognised as exceptional heritage.
Musician and instrument maker Justin Glaie produced a unique lute in 2021, at Museum Vleeshuis' request. This is an instrument of which examples have only survived in Flemish paintings from the first half of the 17th century.
In 2021, Yannick Wijnants of Atelier Herkenrode completed the restoration of the so-called 'Peter Benoit piano', a concert grand piano made by the firm Pleyel, Wolff & Cie in 1884. Thanks to the restoration, this masterpiece was once again playable.
Since 1967, Museum Vleeshuis has kept a superb grand piano by Pleyel, Wolff & Cie. Following a comprehensive restoration in 2020-2021, the instrument was once again playable. Belgian pianist-composer Jeroen Malaise is an ambassador for the 'Pleyel'.